THE AVIAN CELLULAR HOMOLOG OF THE ONCOGENE JUN
- 1 December 1988
- journal article
- research article
- Vol. 3 (6) , 659-663
Abstract
We have isolated chicken genomic and cDNA clones representing the jun oncogene of avian sarcoma virus 17 (ADV17). The genomic clone lacks intron sequences within its protein coding domain, contains a CAAT box, seven SP-1 consensus sequences and TATA box-like elements upstream and two poly(A) addition signals downstream of the coding domain. The cellular jun protein is 310 amino acids in length. Cellular and viral jun proteins differ by three nonconservative amino acid substitutions of which two are located in the DNA-binding domain, by a 27-amino-acid deletion in the amino terminal third of the viral jun protein, by eleven cell-coded amino acids that link the cellular jun coding domain to the viral gag domain and by the partial gag sequences constituting the amino terminal of the viral gag-jun fusion protein. The availability of a cellular jun cDNA now allows the construction of reciprocal recombinants between the viral and the cellular gene which will define the structural features required for the oncogenicity of v-jun.This publication has 17 references indexed in Scilit:
- A lineage-specific gene encoding a major matrix protein of the sea urchin embryo spiculeDevelopmental Biology, 1987
- Structure and organization of the CyIII actin gene subfamily of the sea urchin, Strongylocentrotus purpuratusJournal of Molecular Biology, 1987
- Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression.Proceedings of the National Academy of Sciences, 1987
- Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factorsCell, 1986
- A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradationCell, 1986
- Delimitation and properties of DNA sequence: required for the regulated expression of human interferon-β geneCell, 1985
- Lambda replacement vectors carrying polylinker sequencesJournal of Molecular Biology, 1983
- Structure of a chromosomal gene for human interferon βProceedings of the National Academy of Sciences, 1981
- Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control regionCell, 1981
- DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences, 1977