Synthesis and Properties of 2'-O-Methylribonucleotide Methylphosphonate Containing Chimeric Oligonucleotides

1 May 1995

journal article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 14 (3) , 1031-1035
https://doi.org/10.1080/15257779508012527

Abstract

2′-O-methylribonucleoside methylphosphonamidites are synthesized and incorporated into oligonucleotides to obtain chimeric antisense oligonucleotides. The resulting oligonucleotide binds to their target RNA/DNA sequences efficiently and stable in a medium containing bovine serum.

Keywords

METHYLRIBONUCLEOTIDE METHYLPHOSPHONATE
CONTAINING CHIMERIC
CHIMERIC OLIGONUCLEOTIDES
METHYLPHOSPHONATE CONTAINING
SYNTHESIS AND PROPERTIES

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