Abstract
This manuscript has described the principal modifiable risk factors for the major killer of postmenopausal women. Clearly women who smoke should be convinced to quit, and those who have hypertension and hypercholesterolemia should be encouraged initially to adopt hygienic interventions (that is weight reduction and moderate exercise) to lower their blood pressures and cholesterol levels. Further, given the magnitude of the risk reduction in CVD seen in estrogen users, estrogen use ought to be considered as a preventive therapy for postmenopausal women, but particularly for those who are at high risk of cardiovascular disease.