The Major Histocompatibility Complex — Genetics and Biology

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Abstract
(Third of Three Parts)MHC Control of In Vivo Allograft PhenomenaThe over-riding importance of MHC compatibility for the avoidance of graft-versus-host reactions and for the survival of transplanted organs has been clearly demonstrated. The situation in man is unequivocally proved by kidney transplantations between siblings who have inherited the same HLA haplotypes showing more than 90 per cent long-term survival in the presence of immunosuppressive drugs.40 , 52 HLA SD antigenic identity in unrelated donor-recipient pairs improves graft survival to a much lesser extent than would be expected in view of the sibling data if the SD antigens were the only . . .