Plasmodium Falciparum: Inhibition of in Vitro Growth by Desferrioxamine
- 1 September 1982
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 31 (5) , 919-922
- https://doi.org/10.4269/ajtmh.1982.31.919
Abstract
Infectious agents must acquire iron from their host to survive, and iron deficiency has been reported to protect against malaria in humans. We have tested the the susceptibility of Plasmodium falciparum to iron deprivation by studying the effect of desferrioxamine (DF), a specific iron chelating agent, on parasite growth in an in vitro culture system. We have found that DF inhibits the growth of P. falciparum at concentrations readily achievable in vivo, by a mechanism that may involve interference with the completion of schizogony.This publication has 10 references indexed in Scilit:
- RESISTANCE OF PLASMODIUM FALCIPARUM MALARIA TO SULFADOXINE-PYRIMETHAMINE ('FANSIDAR') IN A REFUGEE CAMP IN THAILANDThe Lancet, 1981
- Early events in guinea pig reticulocyte iron uptakeBiochimica et Biophysica Acta (BBA) - General Subjects, 1981
- Effect of Sodium Cyanate on Plasmodium falciparum In vitroJournal of Parasitology, 1980
- LOW-MOLECULAR WEIGHT NONHEME IRON AND A HIGHLY LABELED HEME POOL IN THE RETICULOCYTE1980
- ANTI-MALARIAL ACTIVITY OF SELECTED AROMATIC CHELATORS1980
- Tetraethylthiuram disulfide (Antabuse) inhibits the human malaria parasite Plasmodium falciparum.Proceedings of the National Academy of Sciences, 1979
- The critical role of iron in host-bacterial interactions.Journal of Clinical Investigation, 1978
- Plasmodium falciparum in Culture: Use of Outdated Erythrocytes and Description of the Candle Jar MethodJournal of Parasitology, 1977
- Effect of Iron Deficiency and Desferrioxamine on DNA Synthesis in Human CellsBritish Journal of Haematology, 1976
- The Biochemistry of Desferrioxamine and its Relation to Iron MetabolismAnnals of the New York Academy of Sciences, 1964