Lack of effect of morphine, reserpine, and halothane on oscillation of plasma insulin in M. mulatta

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Abstract
Oscillating plasma insulin levels, with periods averaging 9 min, in fasting rhesus monkeys were previously reported. To test whether an oscillator in the CNS might be driving these oscillations, 5 male rhesus monkeys were subjected to morphine, reserpine and halothane, agents known to affect the CNS, to either disrupt or change the frequency of the oscillations. No significant effect of any of the 3 drugs on the oscillations was shown. The oscillations in plasma insulin apparently are not driven by an oscillator in the CNS. Coupled with the results of others, these data suggest that these oscillations are probably due to an intrinsic pancreatic pacemaker.