The phosphatases of mammalian tissues

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Abstract
The phosphatases of mammalian tissues have an optimum pH of 8.8-9.3, depending on the character of the substrate. The distribution of phosphatase in tissues of rabbit, cat, and man is remarkably akin to that found for ereptase by Vernon. Other correspondences between these dissimilar enzymes are described. It is probable that the same enzyme is responsible for the hydrolysis of glycerophosphate, hexosediphosphate, and nucleotide. In presence of excess of the alcohol concerned, inorganic phosphate can be esterified, using phosphatases derived from various tissues as catalysts. Glycerophosphoric acid (isolated as the Ba salt) has been synthesized in this way from glycerol, and several other alcohols have been shown to combine with inorganic phosphate. The equilibrium, glycerol + phosphateglycerophosphate + water, has been studied, using phosphatase as catalyst.

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