Influence of adjuvant tamoxifen on blood lymphocytes
- 1 September 1988
- journal article
- research article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 12 (1) , 75-79
- https://doi.org/10.1007/bf01805743
Abstract
The blood lymphocyte population was studied in 23 breast cancer patients treated with adjuvant tamoxifen for 1.5–2 years, and in an equal number of control patients. The size and cellular composition of the blood lymphocyte population, as assessed by monoclonal antibodies directed against various subsets, did not differ between the two patient groups. However, lymphocytes from the tamoxifen-treated patients exhibited a significantly lower NK activity against K562 cells. In contrast, the proliferative response of lymphocytes to ConA was significantly higher. These results indicate that tamoxifen may modulate the immune system.This publication has 17 references indexed in Scilit:
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