Pharmacokinetics of amikacin during continuous veno-venous hemofiltration
- 1 June 1990
- journal article
- case report
- Published by Wolters Kluwer Health in Critical Care Medicine
- Vol. 18 (6) , 675-676
- https://doi.org/10.1097/00003246-199006000-00023
Abstract
We studied the pharmacokinetics of amikacin in a patient with acute oliguric renal failure during continuous veno-venous hemofiltration (CVVH). The volume of distribution, terminal disposition rate constant and elimination half-life for amikacin were 27.9 L, 0.023-h−41 and 29.7 h, respectively. Total body clearance for amikacin was 10.54 ml/min and CWH clearance was 10.11 ml/min. Sieving coefficient for amikacin was 0.93 ± 0.16. Our data show that during CWH at a filtration rate of 10 ml/min, the clearance of amikacin is similar to that reported in patients with renal failure who are not being treated with CVVH. (Crit Care Med 1990; 18:675)Keywords
This publication has 0 references indexed in Scilit: