LECITHIN-CHOLESTEROL ACYLTRANSFERASE AND SERUM FATTY-ACIDS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 9  (4) , 262-274
Abstract
The rate of cholesterol esterification in vitro was significantly lower (.apprx. 20%) in non-obese diabetics than in non-obese controls. More specifically, this decrease was in cholesteryl linoleate synthesis. The concentration of serum free fatty acid, particularly of oleic acid, was .apprx. 2-3 times higher in diabetic patients than in controls. The decreased rate of serum cholesterol esterification was associated with an increase in serum free fatty acid concentration and with a decrease of linoleic acid in serum phospholipids.