Genetic Determinants of Aminoglycoside Resistance in Strains of Mycobacterium Tuberculosis

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Abstract
In this study, evidence of extrachromosomal factors was reported in strains of Mycobacterium tuberculosis naturally resistant and induced in vitro resistant to aminoglycosides with multi-step selection. After resistant strains had been exposed to acridine dyes and ethidium bromide, aminoglycoside-sensitive mutants were recovered. This treatment also eliminated mono- and bi-directional cross-resistance with various combinations of tested antibiotics. The authors suggest that a single plasmidial factor might govern resistance to kanamycin, neomycin, and viomycin in the strains of Mycobacterium tuberculosis, and a separate locus might govern the Sm-resistance.

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