Stability of corticosteroids under anaerobic conditions
- 1 February 1984
- journal article
- Published by Springer Nature in International Journal of Clinical Pharmacy
- Vol. 6 (1) , 1-6
- https://doi.org/10.1007/bf01960189
Abstract
The major decomposition product of prednisolone phosphate formed under anaerobic decomposition conditions in aqueous solution at pH=8.3 is identified as 17a-hydroxy-17a-hydroxymethyl-17-keto-D-homosteroid phosphate. The chromatographic properties, the isolation and the structure elucidation of both the D-homosteroid phosphate and its specific dephosphorylated analogue are given. Finally a mechanism leading to the D-homosteroid phosphate is postulated.Keywords
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