Antiplatelet Therapy

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Abstract
(First of Two Parts)Properties of PlateletsBiologic PropertiesPLATELETS that circulate in the blood do not adhere to each other or to normal endothelium. However, they can adhere and spread on non-endothelial surfaces, aggregate in response to a variety of stimuli, secrete substances such as adenosine diphosphate (ADP) and thromboxane A2 that cause further aggregation, and accelerate blood coagulation. In addition, substances secreted from platelets such as serotonin, prostaglandins, thromboxane A2, mitogens, permeability factors and others can mediate many other biologic reactions.Some of the known or postulated biologic properties of platelets are indicated in Table 1. . . .