EFFICACY OF 2-ROUTE CHEMOTHERAPY USING INTRA-ARTERIAL CISPLATIN AND IV SODIUM THIOSULFATE, ITS ANTIDOTE, IN RAT BLADDER-TUMOR

  • 1 January 1983
    • journal article
    • research article
    • Vol. 67  (6) , 567-572
Abstract
The efficacy of 2-route chemotherapy (TRC) using a combination of cisplatin (DDP) and its antidote, sodium thiosulfate (STS), was evaluated in rat bladder tumor. TRC in which 20 mg/kg of DDP and 2 doses of 1054 mg/kg of STS (100-fold molar ratio to DDP) were given during interruption of arterial flow for 30 minutes through the abdominal aorta and femoral vein, respectively, provided significantly better antitumor effects evaluated by tumor weight and survival time than did intra-arterial or i.v. DDP (4 mg/kg) without STS. These 3 modalities revealed a similar toxicity in rats. Dose- and time-related efficacy of DDP and a high sensitivity of a transitional cell carcinoma of the rat (RBT-1) to DDP were noted in TRC. Nephrotoxicity assessed by increase in BUN [blood urea N] levels was minimum. The particular combination of intra-arterial DDP and i.v. STS presented here is applicable to regionally confined human bladder cancer.