Respiratory and locomotor patterns generated in the fetal rat brain stem-spinal cord in vitro
- 1 April 1992
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 67 (4) , 996-999
- https://doi.org/10.1152/jn.1992.67.4.996
Abstract
An in vitro brain stem-spinal cord preparation from last trimester (E13-E21) fetal rats, which generates rhythmic respiratory and locomotor patterns, is described. These coordinated motor patterns emerge at stages E17-E18. Synchronous rhythmic motor activity, not clearly characterized as respiratory or locomotor, can occur as early as E13. With this preparation, it is now possible to study the ontogenesis of circuits and cellular mechanisms underlying these critical movements.Keywords
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