HISTOCOMPATIBILITY IN THE RABBIT

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Abstract
Rabbits from three inbred lines, all descended from a common ancestor, have very similar, but distinct, RL-A alleles. Leukocytes from rabbits homozygous for these similar alleles do not cross stimulate in the mixed lymphocyte culture (MLC) test. Unrelated, noninbred, RL-A-identical rabbits, produced by genetic crosses of known genotypes, also fail to cross stimulate in the MLC test. Thus, the locus controlling the MLC response and the RL-A locus are closely linked, but not identical. The RL-A-MLC histocompatibility complex is also linked to a third locus, the He blood group locus.

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