Selective distribution of selenium in colon parallels its antitumor activity

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Abstract
The distribution of Se in the different segments of rat colon and the uptake of Se in the mucosa and in the muscle layers of each segment were determined. The colon was perfused before removal of the segments to ensure complete removal of blood-borne Se. The concentration of Se was greater in the proximal colon than in the distal colon and within each segment the uptake was higher in mucosa than in muscle. The level of Se in blood, serum and liver at different times after the administration of various doses was also determined. Though the mechanism by which Se prevents tumor development is unknown, the data indicate a correlation between the uptake of Se in different segments of colon and inhibition of tumorigenesis.

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