19-Hydroxybaccatin III, 10-Deacetylcephalomannine, and 10-Deacetyltaxol: New Antitumor Taxanes From Taxus wallichiana
- 1 May 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 44 (3) , 312-319
- https://doi.org/10.1021/np50015a013
Abstract
Activity-guided, chromatographic fractionation of a polar extract of T. wallichiana Zucc. (originally identified as Cephalotaxus mannii Hook.) resulted in the isolation of 3 new KB [human oral epidermoid carcinoma] cytotoxic taxane derivatives. NMR and mass spectral analyses permitted their characterization as 19-hydroxybaccatin III, 10-deacetylcephalomannine and 10-deacetyltaxol. The latter 2 compounds, which are also active against PS leukemia [mouse lymphocytic] in vivo, were observed to be especially labile, each forming equilibrium mixtures with their cytotoxic C-7 epimers.This publication has 6 references indexed in Scilit:
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