Nucleotide Sequence of an OXA-2 B-Lactamase Gene from the R-Plasmid R1767 Derived Plasmid pBP11 and Comparison to Closely Related Resistance Determinants Found in R46 and Tn2603

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Abstract
Plasmid pBP11 contains a sequence homologous to Tn21-like element Tn2410 encoding dihydropteroate synthetase and beta-lactamase OXA-2. The nucleotide sequence of a 1.5 kb segment of this region has been determined including the bla gene. It reveals strong sequence homology with the OXA-2 operon of plasmid R46. The implications of an additional 319 bp segment in pBP11 for the different evolution of R46/pKM101 and pBP11 are discussed.

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