Epidemiology of congenital pigmented naevi:.

Publisher Website
Google Scholar
Abstract
Genetic and environmental risk factors were investigated in a sample of 989 non-malformed newborn infants with skin pigmented nevi (PN), and in 989 non-malformed non-PN, control babies. The samples were obtained from a population of 531,831 livebirths, from 59 South American maternity hospitals. No significant differences were observed between the PN and control groups for the following risk factors: sex, twinning, parental consanguinity, socioeconomic level, parental ages, birth order, fetal presentation, type of delivery, postnatal mortality and 1st trimester of pregnancy histories for maternal chronic illnesses or immunizations, radiation exposure, drug intake and vaginal bleeding. PN infants were associated with high frequencies of Black racial ancestry, positive prenatal history for maternal acute illnesses and high mean values for length of gestation and birth weight. The observed association of PN with maternal acute illnesses could be a spurious one, due to partial dependence upon Black racial ancestry and to maternal memory bias. The analysis of the intrauterine growth curves showed that PN infants have a low prematurity rate and a high mean birth weight within the postmature group, lacking the normal post-term weight loss pattern shown by the control newborn group. Congenital PN apparently appear in the latest stages of intrauterine development. No evidence was obtained to allow consideration of congenital PN as true developmental anomalies.

This publication has 6 references indexed in Scilit: