Amplification and Rearrangement of Hu- ets -1 in Leukemia and Lymphoma with Involvement of 11q23
- 18 April 1986
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 232 (4748) , 398-400
- https://doi.org/10.1126/science.3457468
Abstract
The Hu-ets-1 oncogene was found to be rearranged and amplified 30-fold in one case of acute myelomonocytic leukemia in which a homogeneously staining region occurred on 11q23; the oncogene was rearranged and amplified approximately tenfold in a case of small lymphocytic cell lymphoma with an inverted insertion that also involved band 11q23. This work suggests that Hu-ets-1 is an unusual oncogene that can help explain the common involvement of chromosome band 11q23 in various subtypes of hematopoietic malignancies.This publication has 29 references indexed in Scilit:
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