ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY

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Abstract
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is an idiopathic posterior segment inflammatory disorder of young adults. The pathophysiology is poorly understood, and debate persists as to whether it represents a primary pigment epithelial disorder or a choroidal vascular disease. Indocyanine green angiography was used to study choroidal blood flow in two patients with typical APMPPE. The authors demonstrate profound delayed choroidal filling in addition to extensive areas of choroidal vessel nonperfusion in the acute stage of this disease. Recovery of choroidal blood flow was evident during clinical resolution. Choroidal blood flow abnormalities are present in APMPPE and suggest that the clinical findings of this disease reflect a primary choroidal vascular disease.

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