Characterization of ciprofloxacin liposomes: Derivative ultraviolet spectrophotometric determinations
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in Journal of Microencapsulation
- Vol. 14 (6) , 769-776
- https://doi.org/10.3109/02652049709006827
Abstract
Neutral, (-) and (+) charged CF encapusulated liposome formulations prepared with EPC:Chol and DPPC:Chol lipids were investigated for their loading capacity, encapsulation % and release properties. CF amounts in the liposomes were estimated using derivative UV spectroscopy. Among the liposome formulations DPPC:Chol and EPC:Chol neutral formulations had a significantly higher loading capacity and slowest release rate compared with (-) and (+) charged liposomes. The derivative UV spectroscopy was found to be an easy and sensitive method for direct estimation of CF in liposomes.Keywords
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