Effect of omeprazole on the secretion of intrinsic factor, gastric acid and pepsin in man.
Open Access
- 1 June 1985
- Vol. 26 (6) , 594-598
- https://doi.org/10.1136/gut.26.6.594
Abstract
The effect of an intravenous infusion of omeprazole (0.35 mg/kg) and placebo on basal and stimulated (pentagastrin 1.0 microgram/kg/h) secretion of gastric acid, intrinsic factor and pepsin was studied in 10 healthy male subjects. Omeprazole caused a marked inhibition of basal and stimulated acid output. The inhibition of pepsin output was less marked, but also significant. The output of intrinsic factor, however, showed no significant change. The results indicate that acid and intrinsic factor might have different secretory mechanisms within the parietal cell.This publication has 31 references indexed in Scilit:
- Effect of omeprazole on gastric secretion in H+,K+-ATPase and in pepsinogen-rich cell fractions from rabbit gastric mucosaBiochemical Pharmacology, 1984
- Inhibition of gastric (H+ + K+)-ATPase by the substituted benzimidazole, picoprazoleBiochimica et Biophysica Acta (BBA) - Biomembranes, 1983
- Effect of substituted benzimidazoles on acid secretion in isolated and enriched guinea pig parietal cells.Gut, 1983
- Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.Gut, 1983
- Effect of Cimetidine on the Absorption of Vitamin B12Scandinavian Journal of Gastroenterology, 1982
- Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPaseNature, 1981
- Histamine H2Receptors and Intrinsic Factor SecretionScandinavian Journal of Gastroenterology, 1980
- Characterization of gastric mucosal membranes. X. Immunological studies of gastric (H+ + K+)-ATPase.The Journal of cell biology, 1979
- Inhibition of intrinsic factor secretion by cimetidine.BMJ, 1978
- Stimulation of human pepsin output by topical hydrochloric acidDigestive Diseases and Sciences, 1975