ADAPTATION OF SKIN ALLOGRAFTS IN MICE TREATED WITH ANTILYMPHOCYTE SERUM

Publisher Website
Google Scholar
Abstract
SUMMARY Mice treated with antilymphocyte serum (ALS) at the time of placement of a firstset skin allograft were grafted additionally with second-set and third-party skin 2 weeks later. The survival of first-set grafts was consistently prolonged beyond the time of rejection of the second-set grafts. Such “adaptation” of first-set grafts was either diminished or abolished in presensitized mice or in mice given additional donor antigen in the form of splenic cells at the time of first-set grafting. Neither enhancing antibody nor residual leukocytes in the graft were thought to be significant factors in facilitating adaptation. The timing of immunosuppressive treatment with respect to the period of vascularization of the allograft by host endothelium may be an important determinant of adaptation.
Keywords

This publication has 0 references indexed in Scilit: