Thrombin-Induced Platelet Aggregation Is Mediated by a Platelet Plasma Membrane-Bound Lectin
- 16 June 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4347) , 1281-1283
- https://doi.org/10.1126/science.663608
Abstract
Throbin-activated human platelets cause agglutination of trypsinized, formalinized bovine erythrocytes. This lectin activity of stimulated platelets was blocked by galactosamine, glucosamine, mannosamine, lysine, and arginine, but not by N-acetylated sugars, other neutral sugars, or other amino acids. Inhibitors of the thrombin-induced lectin activity also blocked thrombin-induced platelet aggregation. It appears that a membrane surface component that has lectin activity mediates platelet aggregation.This publication has 20 references indexed in Scilit:
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