Comparison of early and late naloxone treatment in experimental spinal injury

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Abstract
The effects of early (1 h posttrauma) and late (4 h posttrauma) naloxone treatment on neurologic recovery were compared after experimental cervical spinal injury. Neurologic scores did not differ significantly between the early and late naloxone-treatment groups, and both naloxone groups showed significantly better neurologic recovery than saline-treated controls during a 6 wk follow-up. The opiate antagonists are beneficial for treating experimental spinal injury; even delayed naloxone treatment is effective in improving neurologic outcome.