Autoxidation of Lithio Derivative of 2-Isoxazolines
- 1 January 1988
- journal article
- research article
- Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES
- Vol. 27 (10) , 2395-2402
- https://doi.org/10.3987/com-88-4641
Abstract
4-Lithio-2-isoxazolines are oxidized to the 4-peroxides or 4-hydroxy derivatives by air or oxygen at -80.degree. C. The concentration of oxygen in the solution is a decisive parameter. When it is bubbled into the lithium salt solution, the 4-hydroperoxide derivatives are mainly formed. However if oxygen is slowly absorbed in the liquid phase, 4-hydroxy derivatives predominate. In the reaction, the hydroperoxide anions has been confirmed to be the precursors of the 4-hydroxy-2-isoxazolines.Keywords
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