CLINDAMYCIN (CLEOCIN) COLITIS

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Abstract
Clindamycin (Cleocin) is a synthetic antibiotic used widely against gram-positive and anaerobic organisms. In 6 patients receiving this drug, we have observed the acute onset of colitis lasting several weeks. Barium enema examinations in all patients revealed that 3 had marked mucosal abnormalities and 3 were normal. The changes included diffuse ulcerations, irregular mucosal masses, or uniform nodularity of the entire colon and rectum. The diagnosis is established by the proctoscopic finding of unique cream-colored, plaque-like lesions superimposed on a friable or edematous mucosa.

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