Cryoglobulinemia and Hepatitis C Virus

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Abstract
Lerner and Watson suggested the term "cryoglobulin" to describe a group of proteins with the common property of precipitating from cooled serum.1 On the basis of immunochemical studies of cryoprecipitable proteins from 86 patients, Brouet et al.2 identified three types of cryoglobulins in 1974: Type I consisted of a homogeneous immunoglobulin or free light chains; Type II consisted of a mixture of a homogeneous immunoglobulin (most commonly an IgM-κ M component) with anti-IgG activity (rheumatoid factor) and heterogeneous IgG; and Type III consisted of a mixture of heterogeneous IgM and heterogeneous IgG molecules. The heterogeneous IgM in Type III also . . .