Synthesis of Quinazoline C-Nucleosides: A New Class of 6:6 Bicyclic Purine-Like Analogues.1
- 1 May 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 14 (3) , 397-400
- https://doi.org/10.1080/15257779508012393
Abstract
The quinazoline C-nucleoside congeners of adenosine (1) and inosine (2) have been obtained by radical-induced addition of 4-bromobutyronitrile to C-ribosyl acrylonitrile 10. A base-catalyzed Ziegler-Thorpe cyclization of the dinitrile thus obtained (11) followed by aromatization with DDQ afforded key intermediate 6-ribosylated anthranilonitrile 14 and its α-isomer. Annulation of a pyrimidine ring onto 14 or onto the corresponding o-amino-amide followed by deblocking with MeOH/HCl finally gave 1 or 2 respectively.Keywords
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