Viral Modulation of T-Cell Receptor Signaling
- 1 May 2008
- journal article
- review article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 82 (9) , 4194-4204
- https://doi.org/10.1128/jvi.00059-08
Abstract
To successfully replicate and spread, viruses must take con- trol of multiple cellular processes. Depending on the cell type infected, a virus may drive cellular differentiation, alter cell cycle progression, or inhibit apoptotic pathways to facilitate viral genomic replication and production of progeny virus. In addition, viruses must deal with an inherently hostile environ- ment in the host. Infection induces intracellular antiviral re- sponses; in addition, the immune system seeks to neutralize virus infectivity and destroy infected cells. Among the cells of the immune system, T lymphocytes (T cells) are critically im- portant for the orchestration of the antiviral response and also for the direct killing of infected cells.Keywords
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