EFFECTS OF EXERCISE AND ADRENALINE INFUSION UPON BLOOD-LEVELS OF PROPRANOLOL AND ANTIPYRINE IN HORSE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 205  (3) , 725-731
Abstract
There are now several examples showing that experimentally induced changes in hepatic blood flow can have a marked effect upon the elimination of certain high clearance drugs. Changes in hepatic blood flow produced by exercise might therefore be expected to influence the clearance of these drugs. There was an increase of up to 100%, compared to control values, in the plasma levels of propranolol in horses given either d- or dl-propranolol, 0.2 mg/kg b.wt. [body weight] and then subjected to sustained exercise for 30 min. There was, however, no similar increase with exercise in the plasma levels of antipyrine in horses given antipyrine, 50 mg/kg b.wt. I.v. infusions of adrenaline, 1 .mu.g/kg b.wt. per min for 10 min also produced an increase of about 70% in the plasma levels of d-propranolol.