ANTIBIOTIC EFFECTS ON BACTERIAL COUNTS IN SKIN LESIONS OF EXPERIMENTAL STAPHYLOCOCCAL SKIN INFECTIONS IN THE HAMSTER

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Abstract
We studied the microbiological efficacy of antibiotics on skin infections using experimentally induced skin infection in hamsters.Topical gentamicin (GM), intramuscular injection of GM and oral administration of cephalexin (CEX) were used in hamsters against experimentally induced staphylococcal skin infections. Effects were studied as a function of the dose of cephaloridine (CER) injected intramuscularly at a fixed daily frequency. Effects were also studied as a function of the daily frequency of intramuscular injection of CER at a fixed dose. We found no marked differences in the efficacy of topical application, intramuscular injection, and oral administration. In the dosage study, there were no differences in the efficacy when CER was used at the dosage of 20 mg/kg or more. No differences were found in efficacy when CER was injected twice or more times a day.Topical antibiotic treatment has limitations in the management of skin infection. Skin has a moderate repair activity, so an antibiotic can produce a good clinical course even at a lower concentration than the MIC against a causative organism. The antibiotics studied could give constant efficacy when administered at appropriate doses at fixed frequency or in appropriate frequencies at a fixed dosage.

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