COMPARATIVE EFFECTS OF ANTI-CALCULUS MANAGEMENT IN RAT

1 January 1976

journal article
research article

Vol. 14 (2) , 120-123

Abstract

Utilizing a low pyridoxine, ethylene glycol-fed rat model, various modes of anticalculus therapy were compared. Prophylactic papillary and parenchymal oxalate stone therapy is most effective with MgO. Hydrochlorothiazide is next in order as the therapy of choice in this group. A high Ca diet seems to negate the effect of MgO. Methylene blue, MgO and even sodium phosphate, are not as effective as hydrochlorothiazide in the combined prevention and treatment of preformed parenchymal calcium oxalate stones. No agent seems to have a profound effect on preformed apical papillary calculi.

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