Über die enzymatischen Wirkungen von Pankreas- und Darmsekret (Neunte Mitteilung zur Spezifität tierischer Proteasen.)

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Abstract
Using pancreatic and intestinal proteases from dried glands or intestinal mucous membrane, and also of pancreatic fistula fluid, no qualitative differences were found between the proteolytic effects of the secretion and those of the glandular extracts. In the normal pancreatic secretions the content of the 4 most important enzymes (lipase, amylase, trypsin, and erepsin) was 5-10 times less than that of the crude glycerin extracts of the dried glands. Since the pancreatic secretion is not enzy-matically purer than the gland itself, the higher enzymatic concentration of the enzyme solutions of the dried gland extracts makes them superior for analytical and preparative investigations. Comparison of the ereptic enzymes of the secretion with the erepsin of the glandular extract and with the erepsin of the intestine shows that the 3 are identical.[long dash]From the study of the natural secretion of the intestinal mucous membrane it appears that the intestinal secretions, after a month''s isolation of the small intestine, always contain abundant quantities of erepsin, but no trypsin and still more remarkably, no enterokinase. It is hence concluded that the content of the intestinal mucous membrane depends on the enterokinase of the pancreatic secretion, in which the activator occurs in the form of an inactive precursor.

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