INCREASED SENSITIVITY TO 5-HYDROXYTRYPTAMINE DUE TO INTRAVENTRICULAR ADMINISTRATION OF 5,6-DIHYDROXYTRYPTAMINE

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Abstract
The possibility that intraventricular administration of 5,6-dihydroxytryptamine (5,6-DHT) can cause a development of denervation hypersensitivity to central 5-hydroxytryptamine (5-HT) was examined in rats with special reference to the pituitary-adrenocortical functions. Pretreatment with intraventricular injection of 5,6-DHT itself did not affect the basal concentrations or stress-induced increases of plasma B [corticosterone]. The same pre-treatment elicited augmented responses to s.c. injection of 5-HTP, i.e., there was a significant rise in the concentrations of plasma B as compared with those in the controls. A development of denervation hypersensitivity to 5-HT following intraventricular injection of 5,6-DHT is suggested.