The Role of Cholecystokinin in Radiographic Opacification of the Gallbladder

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Abstract
Studies of the effect of cholecystokinin (CCK) on hepatic elimination of intravenously administered iopanoatc and on gallbladder opacification were performed using nonoperatcd dogs with intact cntcrohcpatic circulation and normal endogenous bile salt pool. Intravenous administration of CCK (3 units/kg) resulted in a 32% increase in apparent transport maximum (maximum rate of elimination) of iopanoatc and earlier and enhanced gallbladder opacification. This increase in apparent transport maximum was abolished by cholecystectomy, indicating that the increase was a result of the release of bile salts from the gallbladder rather than a direct effect of the hormone on the hepatic elimination of iopanoatc The early gallbladder opacification and increased density of contrast material in the gallbladder were related to CCK-induced emptying of the gallbladder and subsequent filling with opacified bile.

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