The Influence of Prenatal Salt on the Development of Hypertension by Spontaneously Hypertensive Rats (SHR)

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Abstract
Spontaneously hypertensive rat (SHR) pups whose mothers receive a high salt diet during pregnancy and who continue on the high salt diet in postnatal life develop exceedingly high blood pressures (230 mm Hg before 4 mo. of age). This does not occur in SHR on high salt only prenatally or only postnatally nor does it occur in Wistar Kyoto (WKY) or Sprague Dawley (CD) rats. Among SHR pups on the high salt regimen both pre and postnatally there is a greatly accelerated incidence of stroke as well as a markedly shortened life-span (36% mortality before 4 mo. of age). Maternal effects of the high salt diet include reduced gestational weight gain and reduced successful pregnancies in SHR and WKY. In successful pregnancies maternal blood pressures in all 3 strains were not significantly altered by the high salt diet. The high salt diet did not affect the life span of the mothers, and the SHR mothers of pups on high salt both pre and postnatally outlived their offspring.

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