Work in Progress: Visualization of Renal Parenchyma by Scintiscanning with Hg203Neohydrin

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Abstract
Radioactive contrast media, such as I131-labeled Diodrast, Miokon, or Hippuran, have been widely used for renal function studies. They are entirely unsatisfactory, however, for renal scintillation scanning because they are rapidly excreted by the kidneys, without retention in the renal parenchyma (Fig. 1, A). In contrast, mercurial diuretics labeled with radioactive mercury are concentrated to a high degree in the renal tubular cells (2), chiefly in the cortex, prior to their appearance in the urine (Fig. 1, B). Furthermore, the nuclide Hg203 has a single, rather weak gamma emission (280 kev) that enables good resolution when a multihole focusing collimator and gamma spectrometry are used (1). These pharmacological and physical characteristics make it possible to obtain a clearly delineated spatial image of the kidneys in man by means of scintillation scanning. The mercurial diuretic is retained in the renal parenchyma long enough to permit completion of the procedure. The effective half-life of the com p...

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