Mechanism of inhibition of lipid peroxidation by tamoxifen and 4‐hydroxytamoxifen introduced into liposomes
- 12 November 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 274 (1-2) , 107-110
- https://doi.org/10.1016/0014-5793(90)81341-k
Abstract
The anticancer drug tamoxifen when introduced into phospholipid liposomes during their preparation inhibited Fe(III)-ascorbate induced lipid peroxidation to a greater extent than similarly introduced cholesterol. Ergosterol was equipotent with tamoxifen, but much less effective than 4-hydroxytamoxifen. Possible mechanisms underlying these effects are discussed in relation to structural mimicry of the sterols by these triphenylethylene drugs as membrane stabilizers against lipid peroxidationKeywords
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