EFFECT OF STEROIDAL SEX-HORMONES ON THE SEX-RELATED DIFFERENCES IN THE HEPATIC ACTIVITIES OF GAMMA-GLUTAMYL-TRANSPEPTIDASE, GLUTATHIONE S-TRANSFERASE AND GLUTATHIONE-PEROXIDASE IN RATS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 45  (2) , 225-232
Abstract
The activities of .gamma.-glutamyltranspeptidase (.gamma.-GTP) and glutathione peroxidase (GSH-Px) were higher in female than in male rat liver. Glutathione S-transferase (GST) activities were conversely higher in males than females. Estradiol administration to castrated rats enhanced the .gamma.-GTP activity. Castration produced a significant increase in GSH-Px activities which was reduced to the control level by subsequent testosterone treatment. Ovariectomized rats had markedly increased the GST activity. These GSH-related enzymes may be subject to modulation by androgenic and estrogenic influences.

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