Induction of Erythema-Wheal Reactions by Soluble Antigen-γE Antibody Complexes in Humans
Open Access
- 1 July 1968
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 101 (1) , 68-78
- https://doi.org/10.4049/jimmunol.101.1.68
Abstract
Summary: The activity of soluble antigen-antibody complexes to induce erythema-wheal reactions in humans was studied using a ragweed antigen-human antibody system. It was found that γE-antibody complexes induced positive skin reactions, whereas neither γG- nor γA-antibody complexes did. The skin reactivity of γE-antibody complexes depended on composition of the complexes. Analysis by sucrose density gradient ultracentrifugation strongly suggests the requirement of two or more antibody molecules for the formation of an active complex. The mechanisms involved in the induction of skin reactivity by the formation of complexes are discussed.Keywords
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