Faculty Opinions recommendation of Cellular targets of gefitinib.
- 20 January 2005
- dataset
- Published by H1 Connect
- Vol. 65 (2) , 379-82
- https://doi.org/10.3410/f.1023941.269741
Abstract
Targeted inhibition of protein kinases with small molecule drugs has evolved into a viable approach for anticancer therapy. However, the true selectivity of these therapeutic agents has remained unclear. Here, we used a proteomic method to profile the cellular targets of the clinical epidermal growth factor receptor kinase inhibitor gefitinib. Our data suggest alternative cellular modes of action for gefitinib and provide rationales for the development of related drugs.Keywords
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