Stimulation of tyrosinase in human melanocytes by pro-opiomelanocortin-derived peptides
- 1 September 1995
- journal article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 146 (3) , 439-447
- https://doi.org/10.1677/joe.0.1460439
Abstract
Human melanocytes, maintained on bovine corneal endothelium-derived extracellular matrix for at least 4 days in the absence of phorbol 12-myristate 13-acetate (PMA) and cholera toxin (CT), displayed increased tyrosinase activity when exposed to several pro-opiomelanocortinderived (POMC) peptides. Melanocytes from 9 of 14 donors showed significantly increased tyrosinase activity after treatment with adrenocorticotropic hormone (ACTH; mean increase 320±107 (s.e.m.)% of control, PPJournal of Endocrinology (1995) 146, 439–447Keywords
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