Vinblastine‐induced microtubular paracrystals in prolactin cells of anterior pituitary gland of lactating rats
- 1 November 1975
- journal article
- research article
- Published by Wiley in Journal of Anatomy
- Vol. 144 (3) , 399-405
- https://doi.org/10.1002/aja.1001440314
Abstract
Vinblastine sulfate in physiological saline was injected directly into the pituitary glands of lactating rats. Injections were made through the ear canal using a syringe equipped with a 24‐gauge needle. The animals were killed at 2, 4, or 6 hours after the injections. When the anterior pituitary glands were examined by electron microscopy, many microtubular paracrystalline deposits were seen in the prolactin and growth hormone cells. The usual cytoplasmic microtubules and microfilaments were not seen in the cytoplasm of these cells. Granular extrusion (exocytosis) was markedly depressed, and an accumulation of secretory granules was definitely observed in the prolactin cells after the administration of vinblastine.Keywords
This publication has 9 references indexed in Scilit:
- Microtubules in Prolactin Cells of the Rat Anterior Pituitary GlandExperimental Biology and Medicine, 1974
- Effect of Anti-mitotic Drugs on the in Vitro Secretory Activity of Mammotrophs and Somatotrophs and on Their MicrotubulesExperimental Biology and Medicine, 1973
- Role of Microtubules in Basal and Stimulated Release of Growth Hormone and Prolactin in Rat Adenohypophysisin VitroEndocrinology, 1973
- Vinblastine-induced paracrystals and unusually large microtubules (macrotubules) in rat renal cellsCell and tissue research, 1973
- Effect of colchicine on rat anterior pituitary gland in tissue cultureExperimental Cell Research, 1972
- Ultrastructural Observation of Pituitary Release of Prolactin in the Rat by Suckling Stimulus*Endocrinology, 1972
- MICROTUBULAR CRYSTALS IN MAMMALIAN CELLSThe Journal of cell biology, 1969