Anti-Inflammatory Activity of Superoxide Dismutases: Inhibition of Adriamycin Induced Edema in Rats
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 2 (1-2) , 19-26
- https://doi.org/10.3109/10715768609088052
Abstract
Various superoxide dismutases from different sources, containing Cu, Mn or Fe at the active centre, have been examined with respect to anti-inflammatory activity in a model using adriamycin-induced edema in rats. Very large differences in efficiency are observed, the most active being E. coli Mn-SOD and bovine Cu-SOD. TheFe-SOD from E coli is active whereas P. leiognathiFe-SODisnot. Human Mn-SOD shows no significant activity and homologous rat Cu-SOD is totally inactive. Yeast Cu-SOD shows proinflammatory properties. Anti-inflammatory activity is not a function of molecular weight or circulation life-time.Keywords
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