A Single Gene Controlling Hemolytic Complement and a Serum Antigen in the Mouse

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Abstract
Summary: Mice of strains deficient in hemolytic complement have been immunized with sera of strains positive for hemolytic complement activity. The resulting antisera react only with sera from mice with hemolytic complement activity. Typing of a variety of individuals for both the serum antigen and complement activity indicate that the same locus, Hc, determines the two. An absorbed rabbit antiserum prepared against the partially purified antigen also reacts only with serum from mice positive for hemolytic complement activity. This suggests that the allele at the complement locus, previously described as Hc0, determines no recognizable product.