Cimetidine increases the pancreatic response to histamine

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Abstract
The effects of histamine alone and histamine plus cimetidine on basal pancreatic exocrine secretion were determined in anaesthetized rabbits with an acute pancreatic cannula. Intravenous histamine administration (0.2–0.8n mol/kg/min) increased pancreatic enzyme secretion. A much greater stimulative effect on pancreatic (cimetidine 4 μmol/kg/min). The results indicate that in the rabbit pancreas the stimulatory effect of histamine is mediated by H1 receptors.