Effect of Pregnancy and of the Menstrual Cycle on Hypoparathyroidism

Publisher Website
Google Scholar
Abstract
Serum and urine calcium and phosphate levels, the serum free calcium level (not bound to protein), creatinine clearance, filtered calcium load, and calculated tubular reabsorption of calcium and of phosphate were studied during 7 pregnancies in 5 women with well-controlled postoperative hypoparathyroidism. Studies of blood and urine levels alone were made in 3 additional pregnant hypoparathyroid women. Serum total calcium level fell due to a fall in the protein-bound moiety, but the filtered calcium load increased as a result of increased glomerular filtration. Despite hypocalcemia and diversion of calcium to the fetal skeleton, urinary excretion of calcium increased because of increased glomerular filtration (the result of normal pregnancy) and decreased tubular reabsorption (the result of vitamin D). Treated hypoparathyroidism had no deleterious effects on the pregnancies or newborns. Nine pregnancies resulted in normal infants; one spontaneous abortion occurred at 3 months. Weekly determinations of serum and urine calcium and phosphate showed no fluctuations with the menstrual cycle in 6 women with well-controlled postoperative hypoparathyroidism. Premenstrual anxiety and tetany in these women are not associated with hypocalcemia.

This publication has 0 references indexed in Scilit: